EC Number   |
Application |
Reference |
|---|
   2.3.2.23 | analysis |
protocol for two-step identification and characterization of physiological E2-E3 pairs. In vivo interacting E2s are identified through bimolecular fluorescence complementation using transient expression in Arabidopsis protoplast. The activity of E2-E3 pairs is analyzed by a synthetic biology approach in which autoubiquitination is reconstituted in bacteria |
778454 |
| 2.3.2.23 | diagnostics |
ubiquitin-conjugating enzyme E2T is an independent prognostic factor and promotes gastric cancer progression |
760224 |
| 2.3.2.23 | drug development |
enzyme Ube2T represents an attractive target for the development of inhibitors. Modulation of DNA repair pathways is a strategy for the development of inhibitors of tumor cell growth, as it can either potentiate the effects of radiotherapy and conventional genotoxins or exploit synthetic lethal interactions |
759600 |
| 2.3.2.23 | drug development |
UbcA1 shows antitumor properties, a potential anticancer drug candidate |
723874 |
| 2.3.2.23 | medicine |
expression of UBE2T is increased in human pancreatic cancer tissues and pancreatic cancer cells. Overexpression of UBE2T significantly promotes pancreatic cancer cell proliferation, migration and invasion. UBE2T downregulation results in the inhibition of pancreatic cancer cell proliferation, migration and invasion |
778830 |
| 2.3.2.23 | medicine |
high expression of UBE2C independently predicts a shorter disease-free survival time of thyroid carcinoma patients. UBE2C also presents a better prognostic performance on the survival probability of patients |
776946 |
| 2.3.2.23 | medicine |
in glioblastoma cells, UBE2S interacts with phosphoglycerate mutase PGAM1 and otubain-2 to inhibit PGAM1 degradation via K48-linked deubiquitylation. This increases PGAM1 protein levels, promoting DNA repair and reducing apoptosis, thereby decreasing the sensitivity of glioblastoma cells to temozolomide |
777687 |
| 2.3.2.23 | medicine |
Ubc-20 is the major enzyme responsible for generating diubiquitinated histone H2B. Loss of Ubc-20 restores wild-type patterns of H3K27me3 oncogenic histone mutation |
779193 |
| 2.3.2.23 | medicine |
UbcH5c is positively correlated with the expression of inhibitor of apoptosis proteins (IAPs) in pancreatic cancer and is overexpressed and associated with a poor prognosis in pancreatic cancer |
778533 |
| 2.3.2.23 | medicine |
UBE2L3 might be a potential therapeutic target to treat SLE and B-cell lymphomas that are characterized by LUBAC hyperactivation and constitutive NF-kappaB signalling |
758749 |
