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Results 1 - 3 of 3
EC Number
Application
Commentary
Reference
medicine
deficiency leads to hyperoxaluria, relative decrease in liver biomass
medicine
involved in renal stone formation, decreased activity due to thiamine deficiency may increase oxalate excretion by 35%
synthesis
application of the E1 component of the Escherichia coli 2-oxoglutarate dehydrogenase multienzyme complex in the synthesis of chiral ompounds with multiple functional groups in good yield and high enantiomeric excess, by varying both the donor substrate (different 2-oxo acids) and the acceptor substrate (glyoxylate, ethyl glyoxylate and methyl glyoxal). The enzyme can accept 2-oxovalerate and 2-oxoisovalerate in addition to its natural substrate 2-oxoglutarate, and the tested acceptors are also acceptable in the carboligation reaction
Results 1 - 3 of 3