EC Number   |
Application |
Reference  |
|---|
    1.14.15.6 | medicine |
treatment of certain hormone-related pathologies |
285428 |
| 1.14.15.6 | medicine |
significant inversed statistical correlation of enzyme immunoreactivity with residual size of tumor in epithelial ovarian carcinoma, but correlation is not an independent prognostic value |
658388 |
| 1.14.15.6 | biotechnology |
the development of a cholesterol biosensor based on screen-printed electrodes modified with multi-walled carbon nanotubes and with the cytochromes P450scc may ensure a high sensitivity. Role of the nanotubes in mediating electron transfer to the cytochrome P450scc is verified as further improved with respect to the case of rhodium-graphite electrodes modified by the use of gold nanoparticles |
702781 |
| 1.14.15.6 | drug development |
the vitamin D3 derivatives produced by the action of P450scc are good candidates for use in the therapy of hyperproliferative disorders |
703625 |
| 1.14.15.6 | analysis |
examination of protein-membrane interactions between P450scc and its redox partners on 1,2-dimyristoyl-sn-glycero-3-phosphocholine membranes containing cholesterol (20%), using a quartz crystal microbalance with dissipation monitoring |
744728 |
| 1.14.15.6 | medicine |
P450scc overexpression in the ventral tegmental area significantly reduces ethanol self-administration of alcohol preferring rats trained to self-administer ethanol, by 20% over the 3 week test period. P450scc overexpression in the nucleus accumbens, does not alter ethanol self-administration. P450scc overexpression produces a 36% increase in (3alpha,5alpha)-3-hydroxypregnan-20-one-positive cells in the ventral tegmental area, but does not increase (3alpha,5alpha)-3-hydroxypregnan-20-one immunoreactivity in nucleus accumbens |
745591 |
| 1.14.15.6 | synthesis |
construction of a fusion protein consisting of cytochrome P450scc (CYP11A1), adrenodoxin and adrenodoxin reductase including 2A peptide from Picornaviridae which is capable of self-cleavage. Introduction to Escherichia coli leads to a high level of expression but no cleavage. In yeast Saccharomyces cerevisiae, the discrete proteins P450scc-2A, adrenodoxin-2A and adrenodoxin reductase are expressed, with a significant proportion present in a fusion adrenodoxin-2A-adrenodoxin reductase. The enzyme system is catalytically active |
745750 |
