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Results 1 - 3 of 3
EC Number Application Commentary Reference
Show all pathways known for 1.1.1.270Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.270analysis enzyme can be used for reconstitution of 4-methyl sterol demethylations of cholesterol biosynthesis from lanosterol 286472
Show all pathways known for 1.1.1.270Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.270medicine the selective inhibition of human 3beta-HSD1 in breast tumors represents a potential treatment for hormone-sensitive breast cancer 725813
Show all pathways known for 1.1.1.270Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.270synthesis used of mutated 3-ketosteroid reductase (Erg27) to obtain radioactive and non-radioactive intermediates of sterol biosynthesis hardly or not available commercially. The strategies are either incubation of cell homogenates of an Erg27-deletant strain with radioactive lanosterol, or incubation of growing cells of a strain expressing point-mutated 3-ketosteroid reductase with radioactive acetate. Chemical reduction of both radioactive and non-radioactive 3-keto sterones gives the physiological 3-beta-OH sterols, as well as the non-physiological 3-alpha-OH isomers 740936
Results 1 - 3 of 3