EC Number |
Natural Substrates |
---|
6.3.4.21 | more |
molecular evolution mechanism |
6.3.4.21 | nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O |
- |
6.3.4.21 | nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O |
lack of the de novo pathway for NAD+ synthesis from tryptophan, utilizes both nicotinic acid and nicotinamide as NAD+ precursors |
6.3.4.21 | nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O |
first step in NAD+-(salvage) biosynthesis |
6.3.4.21 | nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O |
essential for the NAD salvage pathway |
6.3.4.21 | nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O |
NAPRT is essential for nicotinic acid to increase cellular NAD levels and thus to prevent oxidative stress of the cells |