EC Number |
Natural Substrates |
---|
6.3.4.2 | ATP + UTP + glutamine |
CTP synthetase is a cytosolic-associated glutamine amidotransferase enzyme that catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to the C-4 position of UTP to form CTP. CTP is an essential precursor of all membrane phospholipids that are synthesized via the Kennedy, i.e. CDP-choline and CDP-ethanolamine branches, and CDP-diacylglycerol pathways. The URA7-encoded CTP synthetase is responsible for the majority of the CTP made in vivo. Regulation mechanisms, detailed overview |
6.3.4.2 | ATP + UTP + glutamine |
the CTPS1-encoded enzyme is regulated by reversible phosphorylation at Thr455, regulation mechanisms, overview |
6.3.4.2 | ATP + UTP + L-glutamine |
- |
6.3.4.2 | ATP + UTP + NH3 |
- |
6.3.4.2 | ATP + UTP + NH3 |
CTPS1 is involved in microtubule network formation and/or stabilzation, overview |
6.3.4.2 | ATP + UTP + NH4+ |
last step in CTP biosynthesis |
6.3.4.2 | more |
key enzyme for biosynthesis of cytosine ribonucleotides |
6.3.4.2 | more |
the enzyme catalyzes the rate-limiting step in synthesis of cytosine nucleotides from both de novo and uridine-salvage pathways |
6.3.4.2 | more |
rate-limiting enzyme in the synthesis of cytosine nucleotides from both de novo and uridine-salvage pathways. In human lymphoblastic leukemia cells the synthesis of CTP occurs predominantly via CTP synthetase, whereas in proliferating normal human T lymphocytes the salvage of cytidine is preferred |
6.3.4.2 | more |
repression of the pyrG gene encoding cytidine triphosphate synthetase is responsive to cytidine nucleotide levels and is independent of both uridine nucleotides and PyrR-dependent attenuation |