EC Number   |
Natural Substrates |
|---|
    6.3.3.2 | ATP + 5-formyltetrahydrofolate |
- |
| 6.3.3.2 | ATP + 5-formyltetrahydrofolate |
enzyme plays a central role in the regulation of folate-dependent, one-carbon metabolism |
| 6.3.3.2 | ATP + 5-formyltetrahydrofolate |
enzyme plays an important role in one-carbon metabolism, overview about folate catabolism |
| 6.3.3.2 | ATP + 5-formyltetrahydrofolate |
key enzymatic reaction in the pathway by which 5-formyltetrahydrofolate enters the folate coenzyme pool |
| 6.3.3.2 | ATP + 5-formyltetrahydrofolate |
obligatory initial metabolic step in the intracellular conversion of 5-formyltetrahydrofolate to other reduced folates |
| 6.3.3.2 | ATP + 5-formyltetrahydrofolate |
it is proposed that methenyltetrahydrofolate synthetase is a salvage enzyme which converts the nonenzymatically formed and nonmetabolically active 5-formyltetrahydropteroyl-(Glu)n back into the one-carbon donor folate pool. It is also possible that methenyltetrahydrofolate synthetase is part of a regulation system in the cell in which its substrate 5-formyl-tetrahydropteroyl-(Glu)n plays a role as a regulator of one-carbon metabolism by inhibiting other folate requiring enzymes |
| 6.3.3.2 | ATP + 5-formyltetrahydrofolate |
important reaction in one-carbon donor recycling |
| 6.3.3.2 | ATP + 5-formyltetrahydrofolate |
recycling reaction |
| 6.3.3.2 | ATP + 5-formyltetrahydrofolate |
the enzyme affects intracellular folate concentrations by accelerating folate degradation |
| 6.3.3.2 | more |
disruption of folate metabolism is associated with several pathologies and developmental anomalies including cancer and neural tube defects |
