EC Number   |
Natural Substrates |
|---|
    6.2.1.3 | ATP + (R)-ibuprofen + CoA |
(R)-ibuprofenoyl-CoA synthetase and long-chain acyl-CoA synthetase are identical enzymes that are involved in the metabolism of various xenobiotics |
| 6.2.1.3 | ATP + a long-chain carboxylate + CoA |
- |
| 6.2.1.3 | ATP + a long-chain fatty acid + CoA |
- |
| 6.2.1.3 | ATP + a long-chain fatty acid + CoA |
the enzyme can elongate and desaturate fatty acids up to 22:6 |
| 6.2.1.3 | ATP + acylate + CoA |
- |
| 6.2.1.3 | ATP + arachidonate + CoA |
- |
| 6.2.1.3 | ATP + arachidonate + CoA |
preferred substrate |
| 6.2.1.3 | ATP + hexadecanoate + CoA |
- |
| 6.2.1.3 | ATP + long-chain carboxylic acid + CoA |
at 36°C the enzyme is required for the utilization of exogenous myristate by the N-myristoyltransferase. This requirement is not apparent at 24°C or 30°C, suggesting that another acylCoA synthetase activity with differing chain length and/or temperature optima exists |
| 6.2.1.3 | ATP + long-chain carboxylic acid + CoA |
essential role in animal cell proliferation |
