EC Number   |
Natural Substrates |
|---|
    6.1.1.3 | ATP + L-isoleucine + tRNAIle |
the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm |
| 6.1.1.3 | ATP + L-serine + tRNASer |
yeast mitochondrial threonyl-tRNA synthetase MST1 lacks an editing domain and utilizes pre-transfer editing to discriminate against serine. MST1 misactivates serine and edits seryl adenylate (Ser-AMP) in the absence of the cognate tRNA. MST1 hydrolyzes 80% of misactivated Ser-AMP at a rate 4fold higher than that for the cognate threonyl adenylate (Thr-AMP) while releasing 20% of Ser-AMP into the solution. |
| 6.1.1.3 | ATP + L-serine + tRNAThr |
reaction of EC 6.1.1.11, mischarging of tRNAThr |
| 6.1.1.3 | ATP + L-serine + tRNAThr |
reaction of EC 6.1.1.11, mischarging of tRNAThr, low activity |
| 6.1.1.3 | ATP + L-threonine + tRNA1Thr |
- |
| 6.1.1.3 | ATP + L-threonine + tRNA2Thr |
- |
| 6.1.1.3 | ATP + L-threonine + tRNAThr |
- |
| 6.1.1.3 | ATP + L-threonine + tRNAThr |
regulatory mechanism |
| 6.1.1.3 | ATP + L-threonine + tRNAThr |
the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm |
| 6.1.1.3 | ATP + L-threonine + tRNAThr |
the enzyme acts as both an enzyme and a regulator of gene expression, it aminoacylates tRNAThr isoacceptors and binds to its own mRNA, inhibiting its translation, overview |
