EC Number   |
Natural Substrates |
|---|
    5.4.2.8 | alpha-D-glucose 1-phosphate |
- |
| 5.4.2.8 | alpha-D-mannose 1-phosphate |
- |
| 5.4.2.8 | alpha-D-mannose 1-phosphate |
20fold higher activity than with alpha-D-glucose 1-phosphate |
| 5.4.2.8 | alpha-D-mannose 1-phosphate |
PMM/PGM catalyzes the second step in alginate biosynthesis |
| 5.4.2.8 | alpha-D-mannose 1-phosphate |
second step of the alginate biosynthetic pathway |
| 5.4.2.8 | alpha-D-mannose 1-phosphate |
it is unclear whether either glucose or mannose phosphate represents the cellular substrate for SsoPHM. The Km values for rSsoPHM toward glucose 6-phosphate and mannose 6-phosphate are in the low millimolar range, significantly higher than that expected for a physiological substrate. Since the protein encoded by sso0207 is the only identifiable phosphohexomutase in the Sulfolbus solfataricus P2 genome, SsoPHM provides the only recognizable avenue for interconverting glucose 6-phosphate and glucose 1-phosphate during glycogen synthesis and breakdown |
| 5.4.2.8 | D-mannose 6-phosphate |
the enzyme produces mannose 1-phosphate for the synthesis of mannose-1,6-diphosphate as well as of GDPmannose |
| 5.4.2.8 | D-mannose 6-phosphate |
the enzyme is required for synthesis of lipopolysaccharide O side chains |
| 5.4.2.8 | D-mannose 6-phosphate |
conversion to mannose 1-phosphate, which is a substrate for the synthesis of GDPmannose. This nucleotide sugar is then used in the synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of glycosyl-phosphatidyl-inositol anchored proteins |
| 5.4.2.8 | D-mannose 6-phosphate |
first enzyme of the N-glycosylation pathway |
