EC Number   |
Natural Substrates |
|---|
   5.4.2.4 | 2,3-Diphosphoglycerate |
multifunctional enzyme for synthesis and degradation of 2,3-diphosphoglycerte, additional activities are diphosphoglycerate phosphatase and phosphoglycerate mutase |
| 5.4.2.4 | 2,3-Diphosphoglycerate |
in red blood cells 2,3-diphosphoglycerate is the main allosteric effector of hemoglobin, shifting the equilibrium between the oxy and deoxy conformations of hemoglobin preferentially stabilizing the unliganded form. 2,3-Diphosphoglycerate also promotes the polymerization of deoxyhemoglobin in sickle cell disease |
| 5.4.2.4 | 3-phospho-D-glyceroyl phosphate |
- |
| 5.4.2.4 | 3-phospho-D-glyceroyl phosphate |
BPGM plays a pivotal role in the dissociation of oxygen from hemoglobin via 2,3-bisphospho-D-glycerate |
