EC Number   |
Natural Substrates |
|---|
   4.2.2.7 | heparan sulfate |
the enzymatic disruption of heparan sulfate chains on cell surface proteoglycans alters bone morphogenetic protein (BMP) activity and Wnt activity so as to enhance the lineage commitment and osteogenic differentiation of human mesenchymal stem cells |
| 4.2.2.7 | heparin |
- |
| 4.2.2.7 | heparin |
removal of heparin, the anticoagulant required in extracorporal devices for patients undergoing open-heart surgery or kidney dialysis |
| 4.2.2.7 | more |
affinity of the enzyme for different glycosaminoglycans varies, with high substrate specificity toward heparin and heparin-derived polysaccharide. Depolymerization of heparin results in heparin disaccharides as main products |
| 4.2.2.7 | more |
heparinase 1 shows selectivity for 3,6-di-O-sulfo-2-deoxy-2-sulfamido-alpha-D-glucopyranose (1,4) 2-O-sulfo-alpha-L-idopyranosyluronic acid, GlcNS3S6S-IdoA2S, linkages, overview |
| 4.2.2.7 | more |
HepII has a broad specificity |
