EC Number |
Natural Substrates |
---|
4.2.1.20 | (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine |
- |
4.2.1.20 | 1-(indol-3-yl)glycerol 3-phosphate |
alpha-subunit of the bienzyme complex, alpha-reaction |
4.2.1.20 | 1-(indol-3-yl)glycerol 3-phosphate + L-serine |
- |
4.2.1.20 | 1-(indol-3-yl)glycerol 3-phosphate + L-serine |
alpha-subunit of the bienzyme complex, alpha-reaction |
4.2.1.20 | indoleglycerol phosphate |
the reaction is catalyzed by the tryptophan synthase alpha-subunit TrpA |
4.2.1.20 | L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate |
- |
4.2.1.20 | L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate |
Trp is a precursor of several important signalling molecules in Pseudomonas spp., overview |
4.2.1.20 | L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate |
overall reaction |
4.2.1.20 | L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate |
the last two steps of L-tryptophan biosynthesis are catalyzed by Trp synthase, a heterotetramer composed of TrpA and TrpB. TrpB catalyzes the condensation of indole, synthesized by TrpA, and serine to Trp |
4.2.1.20 | L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate |
the tryptophan synthase alpha2beta2 bi-enzyme complex catalyzes the last two steps in the synthesis of L-tryptophan (L-Trp). The alpha-subunit catalyzes cleavage of 3-indole-D-glycerol 3'-phosphate to give indole and D-glyceraldehyde 3'-phosphate. Indole is then transferred from the alpha-subunit to the beta-subunit where it reacts with L-Ser in a pyridoxal 5'-phosphate-dependent reaction to give L-Trp and a water molecule |