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Results 1 - 8 of 8
EC Number Natural Substrates Commentary (Nat. Sub.)
Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.14(5''R)-alpha-5''(6''H)-bithymine + S-adenosyl-L-methionine SPL repairs specifically the 5R isomer. (5''R)-alpha-5''(6''H)-bithymine is the diastereomer produced upon UV irradiation of a TpT dinucleotide
Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.14(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine the enzyme establishes a complex radical transfer cascade and creates a cysteine and a tyrosyl radical dyade to establish repair. This allows the enzyme to solve topological and energetic problems associated with the radical based repair reaction
Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.14(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine -
Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.14(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in double-helical DNA
Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.14(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine (in double helical DNA) + S-adenosyl-L-methionine + 2 H+ -
Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.145,6-dihydro-5-(thymidin-7-yl)thymidine (in double helical DNA) -
Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.14more the (5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine lesion does not absolutely need to be contained within a single or double-stranded DNA for recognition and repaired by the enzyme
Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.14more DNA conformation during in vivo repair and dinucleotide SP TpT flipping process, overview
Results 1 - 8 of 8