EC Number   |
Natural Substrates |
|---|
    4.1.3.39 | (S)-4-hydroxy-2-oxohexanoate |
- |
| 4.1.3.39 | (S)-4-hydroxy-2-oxopentanoate |
- |
| 4.1.3.39 | 4-hydroxy-2-oxovalerate |
- |
| 4.1.3.39 | 4-hydroxy-2-oxovalerate |
last but one step in meta-cleavage pathway for catechol degradation |
| 4.1.3.39 | 4-hydroxy-2-oxovalerate |
step in a meta pathway |
| 4.1.3.39 | 4-hydroxy-2-oxovalerate |
physiological substrate |
| 4.1.3.39 | more |
the enzyme acts in an enzyme complex with the aldehyde dehydrogenase, EC 1.2.1.10, performs the final step in meta-cleavage pathway for catechol degradation |
| 4.1.3.39 | more |
DmpFG is a bifunctional enzyme comprised of an aldolase subunit, DmpG, and a dehydrogenase subunit, DmpF. The aldehyde intermediate produced by the aldolase is channeled directly through a buried molecular channel in the protein structure from the aldolase to the dehydrogenase active site. Binding and channeling of alternative substrates in the enzyme DmpFG, molecular dynamics, overview |
