EC Number |
Natural Substrates |
---|
3.6.5.3 | ATP + H2O |
- |
3.6.5.3 | GDP + H2O |
- |
3.6.5.3 | GTP + H2O |
- |
3.6.5.3 | GTP + H2O |
IF2 in complex with GTP, but not GDP promotes fast association of ribosomal subunits during initiation. IF2 promotes fast formation of the first peptide bond in the presence of GTP, but not GDP. GTP form of IF2 accelerates formation of the 70S ribosome from subunits and GTP hydrolysis accelerates release of IF2 from the 70S ribosome |
3.6.5.3 | GTP + H2O |
importance of GTP hydrolysis in translation initiation for optimal cell growth |
3.6.5.3 | GTP + H2O |
release of peptide promoted by the GGQ motif of class 1 release factors regulates the GTPase activity of RF3. Binding of GTP to RF3 and GTP hydrolysis requires peptide chain release |
3.6.5.3 | GTP + H2O |
elongation factor G catalyzes the translocation step in protein synthesis on the ribosome |
3.6.5.3 | GTP + H2O |
ribosome-dependent GTPase strongly stimulates the binding of initiator tRNA to the ribosomes even in the absence of other factors |
3.6.5.3 | GTP + H2O |
GTP hydrolysis by subunit aIF2gamma |
3.6.5.3 | guanosine 5'-(thio)triphosphate + H2O |
- |