EC Number |
Natural Substrates |
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3.4.24.87 | more |
important role for ADAMTS13 in preventing excessive spontaneous Weibel-Palade body secretion, and in the regulation of leukocyte adhesion and extravasation during inflammation |
3.4.24.87 | more |
ADAMTS13 binds to CD36, a transmembrane protein of endothelial cells and platelets, i.e. glycoprotein IV, not diminishing the proteolytic activity of ADAMTS13, but providing an anchor for ADAMTS13 on the surface of endothelial cells and platelets |
3.4.24.87 | more |
ADAMTS13 contains eight thrombospondin type 1 repeats and binds to CD36, a transmembrane protein present on endothelial cells and platelets. CD36 also binds to thrombospondin-2 via three thrombospondin type 1 repeats in a manner competitive to ADAMTS13, overview |
3.4.24.87 | more |
MDTCS domain modelling and substrate recognition mode analysis, overview |
3.4.24.87 | more |
proteolysis can occur only once VWF has been unraveled from its globular conformation, either by high fluid shear stress in vivo or in the presence of denaturants in vitro, conditions that are able to promote the exposure of the VWF scissile bond |
3.4.24.87 | more |
removal of newly released ultralarge-von Willebrand factor strings or bundles anchored on endothelial cells by ADAMTS13 occurs rapidly and efficiently in the presence and in the absence of fluid shear stress, suggesting that the cell-bound ultra large-von Willebrand factor polymers may be preferred substrates for ADAMTS13 |
3.4.24.87 | more |
thrombospondin1 and ADAMTS13 form complexes together in cells and in direct protein binding assays |
3.4.24.87 | more |
plasmin cleaves and ultimately inactivates the enzyme |
3.4.24.87 | proteins + H2O |
- |
3.4.24.87 | proteins + H2O |
enzyme is involved in thrombotic thrombocytopenic purpura |