EC Number   |
Natural Substrates |
|---|
   3.4.24.36 | Fibronectin + H2O |
- |
| 3.4.24.36 | kappa-B nuclear factor + H2O |
- |
| 3.4.24.36 | more |
protects parasite membrane from cytosolic damage during their survival, differentiation and multiplication in the phagolysosomes of macrophages |
| 3.4.24.36 | more |
Leishmania promastigotes reside in the midgut of the phlebotomine sand fly and invade host macrophages during a sand fly bite, infection may result in leishmanolysin-dependent hydrolysis of MRP, a major protein kinase C substrate in macrophages |
| 3.4.24.36 | more |
enzyme plays a significant role in association with other surface molecules, especially lipophosphoglycan. Overexpression of enzyme can compensate lipophosphoglycan defect in the vertebrate host but in sand flies both molecules fulfill quite different functions |
| 3.4.24.36 | more |
role of enzyme in promastigote multiplication connected with its fibronectin-like properties |
| 3.4.24.36 | more |
major surface protease is a virulence factor of Leishmania spp. protozoan, virulent Leishmania chagasi undergoes a growth-associated lengthening in the t1/2 of surface-localized MSP, but this does not occur in the attenuated L5 strain, surface-localized MSP isoforms are differently regulated in attenuated and virulent strains, overview |
| 3.4.24.36 | more |
the major surface-metalloprotease is a virulence factor which contributes to a variety of functions including evasion of complement-mediated parasite-killing and host intramacrophage survival, the protozoan enzyme protects the parasite against antimicrobial peptide-induced apoptotic killing by the host cell, overview |
| 3.4.24.36 | more |
gp63 is an important agent for suppression of natural killer cells during Leishmain infection. Proliferation of interleukin-2-activated purified natural killer cells is suppressed after exposure to the wild-type but not to gp63ko promastigotes. gp63ko Leishmaina major induces no natural killer cell proliferation when natural killer cells are co-cultured with peripheral blood mononuclear cells populations such as CD14+ monocytes or T cells |
| 3.4.24.36 | more |
gp63 is the principal catalyst of proteolysis during infection. It plays a central role in a number of host cell molecular events that likely contribute to the infectivity of Leishmania |
