EC Number |
Natural Substrates |
---|
3.4.23.46 | amyloid -like PROTEIN 2 + H2O |
- |
3.4.23.46 | amyloid beta-precursor protein + H2O |
- |
3.4.23.46 | amyloid beta-precursor protein + H2O |
BACE1 and the amyloid beta-precursor protein processing pathway are critical for cognitive, emotional and synaptic functions |
3.4.23.46 | amyloid pbeta A4 protein + H2O |
- |
3.4.23.46 | amyloid precursor protein + H2O |
- |
3.4.23.46 | amyloid precursor protein + H2O |
first step in generation of the Abeta peptide is the cleavage of amyloid precursor protein by BACE1. BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper. BACE1 provides a link between metal homoeostasis and oxidative stress in Alzheimer disease |
3.4.23.46 | amyloid precursor protein + H2O |
amyloid precursor protein is cleaved at the N-terminus of Abeta by beta-secretase yielding a slightly shorter soluble APPbeta fragment and a slightly longer CTFbeta fragment (also termed C99) |
3.4.23.46 | amyloid precursor protein + H2O |
BACE1 cleaves amyloid precursor protein at the beta-site |
3.4.23.46 | amyloid precursor protein + H2O |
BACE1 cleaves APP at the N-terminal end of the Abeta sequence, producing a 14000 Da C-terminal fragment beta or C99 |
3.4.23.46 | amyloid precursor protein + H2O |
beta-secretase cleavage produces s-amyloid precursor protein-beta and the beta-C-terminal fragment C99. ATXN1 loss of function potentiates BACE1 cleavage of amyloid precursor protein |