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Results 1 - 10 of 101 > >>
EC Number Natural Substrates Commentary (Nat. Sub.)
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.46amyloid -like PROTEIN 2 + H2O -
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.46amyloid beta-precursor protein + H2O -
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.46amyloid beta-precursor protein + H2O BACE1 and the amyloid beta-precursor protein processing pathway are critical for cognitive, emotional and synaptic functions
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.46amyloid pbeta A4 protein + H2O -
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.46amyloid precursor protein + H2O -
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.46amyloid precursor protein + H2O first step in generation of the Abeta peptide is the cleavage of amyloid precursor protein by BACE1. BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper. BACE1 provides a link between metal homoeostasis and oxidative stress in Alzheimer disease
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.46amyloid precursor protein + H2O amyloid precursor protein is cleaved at the N-terminus of Abeta by beta-secretase yielding a slightly shorter soluble APPbeta fragment and a slightly longer CTFbeta fragment (also termed C99)
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.46amyloid precursor protein + H2O BACE1 cleaves amyloid precursor protein at the beta-site
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.46amyloid precursor protein + H2O BACE1 cleaves APP at the N-terminal end of the Abeta sequence, producing a 14000 Da C-terminal fragment beta or C99
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.46amyloid precursor protein + H2O beta-secretase cleavage produces s-amyloid precursor protein-beta and the beta-C-terminal fragment C99. ATXN1 loss of function potentiates BACE1 cleavage of amyloid precursor protein
Results 1 - 10 of 101 > >>