EC Number   |
Natural Substrates |
|---|
   3.4.22.63 | B cell lymphoma-2-interacting domain + H2O |
caspase-10 can serve as an initiator caspase in Fas signaling leading to Bid processing, caspase cascade activation, and apoptosis |
| 3.4.22.63 | more |
FLICE2 is a signaling caspase able to interact with the cell death receptors p55 and CD95 through the adapter molecule FADD |
| 3.4.22.63 | more |
caspase-10/c is a truncated protein that is essentially a prodomain-only form of the caspase that lacks proteolytic activity in vitro but efficiently induces the formation of perinuclear filamentous structures and cell death in vivo, potential role of caspase-10/c in amplifying the apoptotic response to extracellular stimuli such as cytokines. Caspase-10/d is proteolytically active in vitro and also induces cell death ion vivo, although it is less active than Mch4. Possible role of caspase-10 family in the fetal development |
| 3.4.22.63 | more |
the enzyme acts as initiator of apoptosis |
| 3.4.22.63 | more |
inherited nonlethal caspase abnormalities cause pleiotropic apoptosis defects underlying autoimmunity in ALPS type II, caspase-10 mutations in Pt 11 and Pt 36 affect TRAIL-induced death of dendritic cells |
| 3.4.22.63 | more |
caspase-8 has a role in a non-apoptotic or anti-apoptotic signaling pathway leading to NF-kappaB activation through RIP, NIK and IKKalpha |
| 3.4.22.63 | more |
Mch4 mediates the CrmA-insensitive apoptotic pathways, such as the DNA-damaging agents and staurosporine pathways |
| 3.4.22.63 | more |
caspase-10 actively contributes to cytotoxic drug-induced apoptosis in leukemic cells. Caspase-10 activation does not occur at the level of a death-inducing signaling complex, nor in a Fas-associated death domain-dependent manner, but requires cytochrome c release from the mitochondria and the adapter molecule Apaf-1. Caspase-10 is activated downstream of caspase-9 and amplifies the caspase cascade by activating caspase-9 and caspase-3 in a feedback loop. Caspase-10 plays a role in cytotoxic drug-induced apoptosis downstream of the mitochondria |
| 3.4.22.63 | more |
caspase-10 is involved in RIG-I/Mda5-dependent antiviral immune responses, particularly inflammatory responses |
| 3.4.22.63 | more |
caspase-10 is involved in the early phase of advanced glycation end-product-induced pericyte apoptosis |
