EC Number   |
Natural Substrates |
|---|
   3.4.22.62 | Bcl-2 + H2O |
- |
| 3.4.22.62 | BclxL + H2O |
- |
| 3.4.22.62 | inactive Bid + H2O |
cleavage at amino acid 59 |
| 3.4.22.62 | inactive procaspase-7 variant C186A + H2O |
- |
| 3.4.22.62 | L-histidine decarboxylase precursor + H2O |
in P-815 cells, histamine synthesis is augmented through the post-translational cleavage of L-histidine decarboxylase, which is mediated by caspase-9 |
| 3.4.22.62 | more |
a peroxisome proliferator-activated receptor-gamma agonist, troglitazone, facilitates caspase-8 and -9 activities by increasing the enzymatic activity of protein-tyrosine phosphatase-1B on human glioma cells |
| 3.4.22.62 | more |
activated caspase-9 prevents the accessibility of cytochrome c to complex III, resulting in the production of reactive oxygen species, and that effector caspases may depolarize mitochondria to terminate ROS production and preserve an apoptotic phenotype |
| 3.4.22.62 | more |
activation of caspase-9 is a key step for execution of the maternally preset program of apoptosis shortly after midblastula transition in Xenopus early embryos |
| 3.4.22.62 | more |
although Apaf-1 and caspase-9 are essential for mast cell apoptosis, neither is required for the functional or clonogenic death of the cells, which may be due to mitochondrial dysfunction |
| 3.4.22.62 | more |
caspase-2, -3, -8 and -9 are expressed and active in the rhesus monkey corpus luteum throughout the luteal phase of the natural menstrual cycle. The primary luteotropic hormone of corpus luteum can enhance the activity of effector caspases (-2, -8, and -9) after 3-day exposure |
