EC Number   |
Natural Substrates |
|---|
   3.4.22.49 | Cdc14 + H2O |
separase regulates INCENP-Aurora B anaphase spindle function through activation of Cdc14 |
| 3.4.22.49 | cohesin + H2O |
- |
| 3.4.22.49 | cohesin + H2O |
separase is required for sister chromatid separation during mitosis |
| 3.4.22.49 | cohesin + H2O |
separase, i.e. Esp1, is implicated in the removal of cohesin which links sister chromatids in the S-phase and is postulated to be a specific protease or a positive regulator of protease against cohesin |
| 3.4.22.49 | cohesin + H2O |
separase triggers anaphase by cohesin cleavage, and triggers the release and activation of the phosphatase Cdc14 independently of its protease activity |
| 3.4.22.49 | cohesin + H2O |
separase-mediated cleavage of cohesin at interphase is required for DNA repair. It is proposed that the securin-separase complex might aid DNA repair by removing local cohesin in interphase cells |
| 3.4.22.49 | cohesin + H2O |
cohesin cleavage by human separase requires DNA in a sequence-nonspecific manner |
| 3.4.22.49 | cohesin + H2O |
separase selectively cleaves only the chromosome-associated cohesin with the cofactor chromosomal DNA |
| 3.4.22.49 | cohesin + H2O |
separase selectively cleaves only the chromosome-associated cohesin with the cofactor chromosomal DNA, chromosome-associated cohesin is cleaved preferentially by separase, mechanism |
| 3.4.22.49 | cohesin + H2O |
chromatin-bound cohesion is the preferential substrate |
