EC Number   |
Natural Substrates |
|---|
   3.4.22.46 | eukaryotic initiation factor 4G + H2O |
Lbpro cleaves two homologues of the host cell protein. Lbpro possesses specific binding sites at the non-prime side from S1 down to S7 |
| 3.4.22.46 | eukaryotic initiation factor eIF4G + H2O |
- |
| 3.4.22.46 | eukaryotic initiation factor eIF4G + H2O |
in intermolecular cleavage on polyprotein substrates, isoform Lbpro is unaffected by P1 or P1' substitutions and processes a substrate containing nine eIF4GI cleavage site residues whereas isoform sLbpro fails to cleave the eIF4GI containing substrate and cleaves appreciably more slowly on mutated substrates |
| 3.4.22.46 | eukaryotic initiation factor eIF4GI + H2O |
eukaryotic host cell protein substrate, cleavage prevents the synthesis of host cellular protein from capped cellular mRNAs, while the viral RNA is tsill translated initiating from an internal ribosome entry site |
| 3.4.22.46 | eukaryotic initiation factor eIF4GI + H2O |
eukaryotic host cell protein substrate, recognition/cleavage site is ANLG*RTTL |
| 3.4.22.46 | eukaryotic initiation factor eIF4GII + H2O |
eukaryotic host cell protein substrate, cleavage prevents the synthesis of host cellular protein from capped cellular mRNAs, while the viral RNA is tsill translated initiating from an internal ribosome entry site |
| 3.4.22.46 | eukaryotic initiation factor eIF4GII + H2O |
eukaryotic host cell protein substrate, recognition/cleavage site is LNVG*SRRS, but not ADFG*RQTP |
| 3.4.22.46 | eukaryotic translation initiation factor eIF4GI + H2O |
eukaryotic host cell protein substrate, cleavage causes the rapid inhibition of cellular cap-dependent protein synthesis |
| 3.4.22.46 | eukaryotic translation initiation factor eIF4GI + H2O |
eukaryotic host cell protein substrate, cleavage causes the rapid inhibition of cellular cap-dependent protien synthesis |
| 3.4.22.46 | foot-and-mouth disease leader protein + H2O |
- |
