EC Number |
Natural Substrates |
---|
3.4.22.40 | bleomycin + H2O |
- |
3.4.22.40 | bleomycin + H2O |
bleomycin is a cytotoxic agent inducing pneumonitis, detoxification reaction |
3.4.22.40 | bleomycin + H2O |
detoxification reaction |
3.4.22.40 | bleomycin + H2O |
detoxification reaction, high enzyme expression level leads to resistance against the drug |
3.4.22.40 | bleomycin A2 + H2O |
the enzyme hydrolyzes bleomycins into the biologically inactive deamido bleomycins |
3.4.22.40 | bleomycin B2 + H2O |
the enzyme hydrolyzes bleomycins into the biologically inactive deamido bleomycins |
3.4.22.40 | deiminated filaggrin + H2O |
neutral cysteine protease bleomycin hydrolase is essential for the breakdown of deiminated filaggrin into amino acids |
3.4.22.40 | homocysteine-thiolactone + H2O |
- |
3.4.22.40 | huntingtin + H2O |
the enzyme is involved in a specific cleavage step at the N-terminal fragment cp-2 site of huntingtin |
3.4.22.40 | L-homocysteine-thiolactone + H2O |
- |