EC Number   |
Natural Substrates |
|---|
   3.4.22.36 | Bap31 protein + H2O |
- |
| 3.4.22.36 | epidermal growth factor receptor + H2O |
cleavage during apoptosis |
| 3.4.22.36 | interferon-gamma inducing factor + H2O |
cleavage site: LESD-/- |
| 3.4.22.36 | interleukin-1 + H2O |
- |
| 3.4.22.36 | interleukin-18 + H2O |
caspase-1 is required for control of oral infection with wild-type Salmonella in mice, as well as for resistance to septic shock following systemic challenge with live attenuated Salmonella enterica serovar typhimurium. Furthermore host defense against Salmonella enterica serovar typhimurium requires both caspase-1 substrates IL-1beta and IL-18 |
| 3.4.22.36 | interleukin-1beta + H2O |
caspase-1 is required for control of oral infection with wild-type Salmonella in mice, as well as for resistance to septic shock following systemic challenge with live attenuated Salmonella enterica serovar typhimurium. Furthermore host defense against Salmonella enterica serovar typhimurium requires both caspase-1 substrates IL-1beta and IL-18 |
| 3.4.22.36 | more |
the enzyme is involved in cytokine activation |
| 3.4.22.36 | more |
phenotype of aninmals deficient in caspase-1: defective lipopolysaccharide-induced secretion of interleukin-1alpha and interleukin-beta and gamma-interferon, resists endotoxic shock, thymocytes partially resistant to Fas-mediated apoptosis |
| 3.4.22.36 | more |
the production of the active enzyme induces the activation of an endogenous 32000 Da (CPP32) like caspase |
| 3.4.22.36 | more |
cell death protease essential for development. Loss of zygotic caspase-1 function in Drosophila causes larval lethality and melanotic tumors |
