EC Number   |
Natural Substrates |
|---|
   3.4.22.32 | CD25 + H2O |
bromelain proteolytically cleaved cell-surface CD25 from activated CD4+ T cells, a mechanism of action to exert therapeutic benefits in inflammatory conditions, overview |
| 3.4.22.32 | more |
enzyme reduces the amount of prostaglandin-E2 and substance P in vivo in inflammatory process in rats, while in vitro it induces an increase in the concentration of these inflammation mediators, thus the enzyme does not directly interact with the compounds, but has an antiinflammatory effect in vivo |
| 3.4.22.32 | more |
bromelain from pineapple stem shows therapeutic benefits in a variety of inflammatory diseases, including murine inflammatory bowel disease, mechanism, overview. Bromelain primary long-term effect is abrogation of firm adhesion of leukocytes to blood vessels at the site of inflammation. These changes in adhesion are correlated with rapid re-expression of the bromelain-sensitive CD62L/L-selectin molecules that mediate rolling following in vivo bromelain treatment and minimal re-expression of CD128 |
| 3.4.22.32 | more |
bromelain possesses anti-inflammatory activity and reduces blood viscosity, prevents the aggregation of blood platelets, and improves ischemia-reperfusion injury, I/R, in a skeletal muscle model in adult Sprague-Dawley rats. The enzyme increases phosphorylation of Akt in rat heart both in the cytosolic and the nuclear fraction following I/R |
| 3.4.22.32 | more |
CD4+ T cells retain the ability to divide after bromelain treatment |
| 3.4.22.32 | more |
effects of orally administered bromelain in an ovalbumin-induced murine model of acute allergic airway disease in female C57BL/6J mice, bromelain causes decreased methacholine sensitivity, reduction in bronchoalveolar lavage eosinophils and interleukin-13 concentrations, as well as of CD19+ B cells and CD8+ T cells, as compared with controls, overview. Bromelain modulates lung lymphocytes during acute asthma |
| 3.4.22.32 | more |
phosphorylation and consequent degradation of IkappaBalpha, the inhibitor of the nuclear importing sequences of NF-kappaB, is blocked by bromelain, which also shows anti-inflammatory, anti-invasive and anti-metastatic properties, anti-tumor-initiating effects of bromelain in 2-stage mouse skin tumorigenesis model, overview. Bromelain treatment resulted in upregulation of p53 and Bax and subsequent activation of caspase 3 and caspase 9 with concomitant decrease in Bcl-2, and bromelain inhibits DMBA-induced DNA alkylation damage, overview |
| 3.4.22.32 | P-selectin glycoprotein ligand-1 + H2O |
- |
| 3.4.22.32 | protein + H2O |
- |
