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Results 1 - 9 of 9
EC Number Natural Substrates Commentary (Nat. Sub.)
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.98CARDIF + H2O NS3-4A cleaves Cardif (adaptor protein of retinoic acid-inducible gene I or melanoma differentiation-associated gene-5), resulting in an interruption of the Cardif-mediated pathway in non-neoplastic human hepatocyte PH5CH8 cells
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.98CARDIF + H2O NS3-4A cleaves Cardif (CARD adaptor-inducing) by generating a 70 kDa fragment. NS3-4A-mediated cleavage, is not caspase-dependent. Cardif mutant C508A is resistant to NS3-4A-mediated cleavage
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.98caspase recruitment domain adaptor-inducing IFN-beta (Cardif) + H2O -
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.98hepatitis C virus polyprotein + H2O mutational cleavage
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.98hepatitis C virus polyprotein + H2O the enzyme is essential for processing of viral polyprotein
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.98hepatitis virus C polyprotein + H2O maturation of the viral polyprotein
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.98mitochondrial antiviral signaling protein + H2O i.e. MAVS, cleavage at Cys-508
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.98more NS3-4A lacks the ability to cleave endogenous TRIF, regardless of HCV strains derived from patients with different stages of hepatic disease. Inflammatory cytokine production by NF-kappaB activation via the TRIF-mediated pathway also remains unsuppressed by NS3-4A
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.98more NS3/4A protease is responsible for cleaving the viral polyprotein at junctions 3-4A, 4A4B, 4B5A, and 5A5B and two host cell adaptor proteins of the innate immune response, TRIF and MAVS
Results 1 - 9 of 9