EC Number   |
Natural Substrates |
|---|
   3.4.21.89 | core protein of classical swine fever virus + H2O |
the processing of core protein of classical swine fever virus is conducted by signal peptide peptidase. Inhibition of this enzyme results in a reduced virus yield |
| 3.4.21.89 | hepatitis C virus core protein + H2O |
signal peptide peptidase-catalyzed cleavage of hepatitis C virus core protein is dispensable for virus budding, but destabilizes the viral capsid |
| 3.4.21.89 | intermediate of cytochrome c peroxidase + H2O |
Pcp1 is involved in processing of the intermediate of cytochrome c peroxidase |
| 3.4.21.89 | more |
the physiological role is to release exported proteins from the membrane by removing the leader sequence |
| 3.4.21.89 | more |
the enzyme removes amino-terminal leader peptides from exported proteins after they have crossed the plasma membrane |
| 3.4.21.89 | more |
in addition to naturally occuring precursor protein substrates, signal peptidase can process short, synthetic peptide substrates based on the cleavage site region of pre-maltose binding protein and M13 procoat, minimum length for cleavage of peptide substrates is 5 residues, -3 to + 2 of the pre-maltose binding protein, indicating that the recognition sequence for signal peptidase lies between the -3 and +2 position |
| 3.4.21.89 | more |
Inactivation of sipX does not effect intracellular multiplication of Listeria monocytogenes but significantly reduces bacterial virulence (about 100fold). Inactivation of sipZ impairs the secretion of phospholipase C and listeriolysin O, restricts intracellular multiplication and almost abolishes virulence. Inactivation of sipY has no detectable effects |
| 3.4.21.89 | more |
the enzyme is required for dislocation from the endoplasmic reticulium |
| 3.4.21.89 | more |
the enzyme is responsible for the full maturation of Toc75, the protein translocation channel at the plastid outer envelope membrane. the enzyme is required for biogenesis of plastid internal membranes |
| 3.4.21.89 | more |
the maturation of the core protein of hepatitis C virus is controlled by signal peptide peptidase Homo sapiens |
