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EC Number
Natural Substrates
Commentary (Nat. Sub.)
3.4.21.83
Atrial natriuretic factor + H2O
cleavage at four sites: Arg3-Arg4, Arg4-/-Ser5, Arg11-/-Ile12, and Arg27-Tyr28, thereby abrogating smooth muscle relaxant and prohypotensive properties of atrial natriuretic factor. The in vitro half-life of atrial natriuretic factor in rat plasma is reduced 300fold in plasma from Trypanosoma evansi infected rodents, which contain high levels of OpdB activity. Oligopeptidase B plays a role in peptide hormone dysregulation in trypanosomiasis, specifically in generating the depressed plasma levels of atrial natriuretic factor in mammals infected with trypanosoma evansi
3.4.21.83
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involved in host cell invasion
3.4.21.83
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the enzyme may be associated with Chagas disease pathogenesis nb yhydrolyzing host proteins and inducing host immune responses
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