EC Number   |
Natural Substrates |
|---|
   3.4.21.77 | Fibronectin + H2O |
- |
| 3.4.21.77 | Fibronectin + H2O |
enzyme participates in sperm liquefaction by cleaving fibronectin and semenogelins, the major components of the seminal vesicle coagulum after ejaculation |
| 3.4.21.77 | Galectin-3 + H2O |
carbohydrate-binding protein involved in cell adhesion, cell cycle control, immunomodulation, and cancer progression, including prostate cancer |
| 3.4.21.77 | Galectin-3 + H2O |
galectin-3 Tyr-107 is phosphorylated by c-Abl. It can be cleaved at this site by the enzyme after Tyr107, resulting in loss of galectin-3 multivalency while preserving its carbohydrate binding activity |
| 3.4.21.77 | insulin-like growth factor binding protein-3 + H2O |
- |
| 3.4.21.77 | more |
enzyme is regulated by steroid hormones, it contains 2 androgen-response elements in the proximal PSA promotor |
| 3.4.21.77 | more |
stimulates cell detachment and facilitates tumor spread |
| 3.4.21.77 | more |
enzyme can be activated by recombinant kallikrein 2 |
| 3.4.21.77 | plasminogen + H2O |
- |
| 3.4.21.77 | polypeptide + H2O |
- |
