EC Number   |
Natural Substrates |
|---|
   3.4.21.43 | C3 zymogen + H2O |
activation |
| 3.4.21.43 | C5 zymogen + H2O |
activation |
| 3.4.21.43 | complement component C3 + H2O |
- |
| 3.4.21.43 | complement component C3 + H2O |
complement component C3 is the preferred substrate. Cleavage of the preferred C3 substrate and deposition of C3b effectively switches the output of the enzyme from C3b to C5b, resulting in initiation of the cytosolic process of complement |
| 3.4.21.43 | complement component C3 + H2O |
C3 complement cleavage is a central event in the activation of the complement system via the classical, the alternative, and the lectin pathway, overview |
| 3.4.21.43 | complement component C3 + H2O |
classical pathway of the complement system |
| 3.4.21.43 | complement component C5 + H2O |
- |
| 3.4.21.43 | complement component C5 + H2O |
C5 convertases C4b2aC3b and C3b 2 Bb |
| 3.4.21.43 | complement component C5 + H2O |
C5 convertases, C4b2a3b and C3b2Bb, cleave C5 into the anaphylatoxin C5a and C5b followed by initiation of the terminal pathway, leading to formation of lytic C5b-9 membrane attack complexes, overview |
| 3.4.21.43 | complement component C5 + H2O |
C5 convertases, C4b2a3b and C3b2Bb, cleave C5 into the anaphylatoxin C5a and C5b, overview |
