EC Number   |
Natural Substrates |
|---|
   3.2.2.6 | cyclic ADP-ribose + H2O |
- |
| 3.2.2.6 | more |
enzyme is involved in the regulation of intracellular concentration of adenosine diphosphoribose |
| 3.2.2.6 | more |
enzyme may be induced by presence of protein in the culture medium. Low concentrations of sucrose or glucose, 0.1%, casamino acids or some amino acids such as Met, Cys, Phe and Trp strongly repress enzyme synthesis |
| 3.2.2.6 | more |
CD38 is a NAD+-dependent, multifunctional ectoenzyme that cannot only generate cyclic ADP-ribose from NAD+ but also hydrolyze cyclic ADP-ribose to ADP-ribose and transport cyclic ADP-ribose into cells |
| 3.2.2.6 | more |
frog CD38 enzyme shows NAD+ glycohydrolase, ADP-ribosyl cyclase, and cyclic ADP-ribosyl hydrolase activities |
| 3.2.2.6 | more |
the enzyme catalyses the hydrolysis of NAD+ into nicotinamide and ADP-ribose and the formation of cyclic ADP-ribose (cADPR) |
| 3.2.2.6 | NAD+ |
- |
| 3.2.2.6 | NAD+ + H2O |
- |
| 3.2.2.6 | NAD+ + H2O |
overall reaction |
| 3.2.2.6 | NAD+ + H2O |
bovine CD38/NAD+ glycohydrolase catalyzes the hydrolysis of NAD+ to nicotinamide and ADP-ribose and the formation of cyclic ADP-ribose via a stepwise reaction mechanism |
