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EC Number
Natural Substrates
Commentary (Nat. Sub.)
3.2.2.28
hypoxanthine-mismatched double-stranded DNA + H2O
the enzyme also acts as a hypoxanthine DNA glycosylase with the strongest activity on the G/I base pair but no activity detected on the C/I base pair
3.2.2.28
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Mug is expressed poorly in exponentially growing cells and has no apparent role in mutation avoidance in these cells. Mug is fairly abundant in stationary-phase cells and has an important anti-mutator role at this stage of cell growth
3.2.2.28
uracil-mismatched double-stranded DNA + H2O
the enzyme acts as a double-stranded uracil DNA glycosylase with a relatively low activity on the A/U base pair
3.2.2.28
xanthine-mismatched double-stranded DNA + H2O
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3.2.2.28
xanthine-mismatched single-stranded DNA + H2O
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