EC Number   |
Natural Substrates |
|---|
   3.2.2.17 | DNA + H2O |
- |
| 3.2.2.17 | DNA + H2O |
UV-irradiated DNA, containing thymine dimers |
| 3.2.2.17 | DNA + H2O |
pyrimidine cyclobutane dimer formed between adjacent pyrimidines |
| 3.2.2.17 | DNA + H2O |
removal of UV-induced pyrimidine dimer photoproducts |
| 3.2.2.17 | more |
UV-specific endonuclease inactive on UV single-stranded DNA, N-glycosylase activity less active on single-stranded substrate |
| 3.2.2.17 | more |
only nicking of UV-irradiated DNA, creating phospho diester bond breaks 5' with respect to pyrimidine dimers, protein containing the glycosylase activity also contains the apyrimidinic endonuclease activity, multifunctional enzyme, 2 distinct domains in a single enzyme molecule possess both pyrimidine dimer-DNA glycosylase, and AP endonuclease activity, first the glycosylase cleaves glycosylic bond of one of the pyrimidine residues of a dimer to yield an AP site, then AP endonuclease hydrolyzes the phospho diester bond near the AP site, prefers duplex DNA to single-stranded |
| 3.2.2.17 | more |
the enzyme reduces the incidence of basal-cell and squamous cell carcinoma in mice. Treatment of Cdk4(R24C/R24C)/Nras(Q61K) mice topically with the T4 endonuclease V DNA repair enzyme immediately prior to neonatal ultraviolet radiation (UVR) exposure has a powerful effect in exacerbating melanoma development, overview |
