EC Number   |
Natural Substrates |
|---|
   3.2.1.143 | more |
enzyme is a necessary component of the poly(ADP-ribose) polymerase 1 mediated cell death pathway |
| 3.2.1.143 | more |
shuttling of enzyme between nucleus and cytoplasm and proper control of poly(ADP-ribose) metabolism throughout cell cycle may be an important role in regulating cell cycle progression and centrosome duplication |
| 3.2.1.143 | more |
transient decrease in nuclear enzyme activity is important for the onset of differentiation of HL-60 cells to macrophage-like cells |
| 3.2.1.143 | more |
enzyme activity modulates the inflammatory response and tissue events associated with spinal cord trauma and participates in target organ damage under these conditions |
| 3.2.1.143 | more |
poly(ADP-ribose) glycohydrolase is a critical component of single-strand break repair and accelerates this process in concert with poly(ADP-ribose) polymerase |
| 3.2.1.143 | more |
poly(ADP-ribose) polymerase and poly(ADP-ribose) glycohydrolase promote chromatin silencing at least in part by regulating the localization and function of silencing protein SIR2 and possible other nuclear proteins |
| 3.2.1.143 | more |
function in cell death |
| 3.2.1.143 | more |
several isoforms, functions in embryonic development, genotixicity, cell cycle regulation, mitotic spindle assembly, development, differentiation, and cell death |
| 3.2.1.143 | more |
poly(ADP-ribose) glycohydrolase is the only enzyme known to catalyse hydrolysis of the O-glycosidic linkages of ADP-ribose polymers |
| 3.2.1.143 | more |
the enzyme functions as an endo-glycosidase to release oligo(ADP-ribose) and as an exo-glycosidase to release ADP-ribose. Long poly(ADP-ribose) polymers are efficiently hydrolyzed by a combination of endo- and exo-glycosidic activity, whereas smaller digestion products are poor substrates for the enzyme allowing release of oligo(ADP-ribose) chains that are ligands for histones and DNA repair and damage checkpoint proteins such as XRCC1 and p53 |
