EC Number   |
Natural Substrates |
|---|
   3.2.1.114 | 3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose + H2O |
- |
| 3.2.1.114 | 4-methylumbelliferyl alpha-D-mannopyranoside + H2O |
- |
| 3.2.1.114 | GlcNAc(Man)5GlcNAc + 2 H2O |
natural substrate, involved in the processing of N-linked oligosaccharides |
| 3.2.1.114 | GlcNAcMan5GlcNAc2 + H2O |
- |
| 3.2.1.114 | high mannose N-glycan + H2O |
- |
| 3.2.1.114 | Man5GlcNAc2 + H2O |
- |
| 3.2.1.114 | Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-1-Asn + H2O |
physiological substrate, conversion by sequential removal of two alpha1,6-linked and alpha1,3-linked mannose residues from the alpha-1,6-branch of the substrate |
| 3.2.1.114 | Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 H2O |
alpha-mannosidase IIx, M6Gn2 is the primary target in vivo, integral part of N-glycan biosynthesis |
| 3.2.1.114 | Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 H2O |
alpha-mannosidase II, biosynthesis of N-glycans |
| 3.2.1.114 | Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 H2O |
involved in N-glycan maturation, acts after GlcNAc transferase I to remove 2 mannose residues to form GlcNAc(Man)3(GlcNAc)2 prior to extension into complex N-glycans |
