EC Number   |
Natural Substrates |
|---|
   3.1.4.35 | 3',5'-cGMP + H2O |
- |
| 3.1.4.35 | 3',5'-cGMP + H2O |
allosteric cGMP-binding sites of PDE5 could regulate cGMP signaling by sequestering cGMP from cGMP-dependent protein kinase and perhaps from the PDE5 catalytic site as well. The cGMP sequestered by binding of cGMP to PDE5 R domain significantly dampens activation of cGMP-dependent protein kinase and hydrolysis of cGMP by PDE5 C domain |
| 3.1.4.35 | 3',5'-cGMP + H2O |
suPDE5 regulates cGMP levels in sperm, which in turn modulate sperm motility |
| 3.1.4.35 | 3',5'-cGMP + H2O |
PDE5 and PDE6 show specificity for cGMP relative to cAMP |
| 3.1.4.35 | 3',5'-cGMP + H2O |
PDE5 is cGMP-specific |
| 3.1.4.35 | 3',5'-cGMP + H2O |
PDE5 specifically targets 3',5'-cyclic GMP |
| 3.1.4.35 | 3',5'-cGMP + H2O |
phosphodiesterase 5 converts the second messenger 3',5'-cGMP to its inactive form |
| 3.1.4.35 | guanosine 3',5'-cyclic phosphate + H2O |
- |
| 3.1.4.35 | guanosine 3',5'-cyclic phosphate + H2O |
very low activity with cAMP |
| 3.1.4.35 | more |
human chorionic gonadotropin reduces PDE5 expression and enzyme activity in smooth muscle cells, possibly through a pathway involving cAMP |
