EC Number |
Natural Substrates |
---|
3.1.4.17 | 3',5'-cAMP + H2O |
- |
3.1.4.17 | 3',5'-cAMP + H2O |
inhibition of cAMP hydrolysis by cGMP is likely to contribute to cGMP-mediated signaling in myocardium |
3.1.4.17 | 3',5'-cGMP + H2O |
- |
3.1.4.17 | 3',5'-cGMP + H2O |
PDE1 and PDE2 are the main PDEs that act to degrade cGMP in methacholine-stimulated cells |
3.1.4.17 | 3',5'-cGMP + H2O |
highest affinity for 3',5'-cGMP |
3.1.4.17 | more |
overview on physiological role |
3.1.4.17 | more |
h-prune activity is suppressed by dipyridamole and enhanced by the interaction with nm23-H1. Activity is involved in promoting cancer metastasis |
3.1.4.17 | more |
insulin-induced activation of the membrane bound PDE3B is a key step in insulin-mediated inhibition of lipolysis and is also involved in the regulation of insulin-mediated glucose uptake and lipogenesis in adipocytes |
3.1.4.17 | more |
muscarinic antagonists acting possibly as inverse agonists on M2/M3 muscarinic acetylcholine receptors anchored to sarcolemma membranes can initiate a new signal transducing cascade leading to inhibition of PDEI, which produces a simultaneous rise in both cAMP and cGMP intracellular levels in tracheal smooth muscle |
3.1.4.17 | more |
PDE1 in Pukinje neurons may play a role in limiting the cGMP-mediated long-term depression response |