EC Number   |
Natural Substrates |
|---|
   3.1.4.12 | a sphingomyelin + H2O |
- |
| 3.1.4.12 | more |
- |
| 3.1.4.12 | more |
a deletion in the gene encoding sphingomyelin phosphodiesterase 3 results in osteogenesis and dentinogenesis imperfecta in the mouse |
| 3.1.4.12 | more |
acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor - induced lethal hepatitis |
| 3.1.4.12 | more |
an inherited deficiency of this enzymatic activity results in the type A and B forms of Niemann-Pick disease |
| 3.1.4.12 | more |
caspase 8 activates neutral sphingomyelinase in rafts in oligodendrocytes |
| 3.1.4.12 | more |
expression of neutral sphingomyelinase-2 in primary rat hepatocytes modulates IL-beta-induced JNK activation |
| 3.1.4.12 | more |
key enzyme of sphingolipid metabolism and sphingolipid-induced signaling. The enzyme is a contributor to the increased stress and inflammatory sensitivity amoung the brain regions with age |
| 3.1.4.12 | more |
modification of the SMase/SM-synthase balance, shown in the nuclei 1 h after serum deprivation, appears specific for the early events of the apoptotic process |
| 3.1.4.12 | more |
neutral sphingomyelinase is a key component of the signaling pathway in cytokine- and other stress-induced cellular responses |
