EC Number |
Natural Substrates |
---|
3.1.21.7 | deoxyinosine-containing deoxyoligonucleotide + H2O |
the enzyme is involved in damaged DNA repair |
3.1.21.7 | DNA + H2O |
5'-GCTCGGCTICGGACCGAG-3'. Endonuclease V is an inosine-specific nucleases that cleave at the second phosphodiester bond 3' to inosine |
3.1.21.7 | DNA + H2O |
endonuclease V recognizes deoxyinosine and cleaves the second phosphodiester bond on the 3' side of the deaminated base lesion in damaged DNA. The enzyme possesses specific endonuclease activity for the deoxyinosine-containing DNA strand |
3.1.21.7 | DNA + H2O |
the enzyme binds A:TT loops with higher affinity than undamaged DNA |
3.1.21.7 | DNA + H2O |
the enzyme cleaves the second phosphodiester bond 3' to deoxyinosine |
3.1.21.7 | DNA + H2O |
endonuclease V is an important enzyme for repairing deoxyinosine in DNA |
3.1.21.7 | DNA + H2O |
- |
3.1.21.7 | DNA + H2O |
cleavage of both denatured and native eukaryotic DNA |
3.1.21.7 | DNA + H2O |
pyrimidine dimer-specific |
3.1.21.7 | DNA + H2O |
also nicks duplex DNA exposed to OsO4, x-rays or acid, does not act upon undamaged DNA or irradiated single-stranded DNA |