EC Number   |
Natural Substrates |
|---|
   3.1.21.2 | double-stranded alkylated DNA + H2O |
endonucleolytic cleavage of DNA into 5'-phosphooligonucleotides |
| 3.1.21.2 | double-stranded alkylated DNA + H2O |
in vivo the enzyme produces mostly double-stranded fragments with a few internal nicks |
| 3.1.21.2 | double-stranded nativeDNA + H2O |
endonucleolytic cleavage of DNA into 5'-phosphooligonucleotides |
| 3.1.21.2 | more |
endonuclease IV encoded by denB of bacteriophage T4 is implicated in restriction of deoxycytidine (dC)-containing DNA in the host Escherichia coli |
| 3.1.21.2 | more |
role for Endo IV to counteract DNA damage induced by the oxidative counterpart of UVB in Escherichia coli |
| 3.1.21.2 | more |
a His-tagged derivative of ScoA3McrA cleaves S-modified DNA and also Dcm-methylated DNA in vitro near the respective modification sites. Sco4631 cleaves DNA at multiple possible sites on either side of the S-modification. Double-strand cleavage occurs 16-28 nucleotides away from the phosphorothioate links |
| 3.1.21.2 | more |
EndoII primarily catalyzes single-stranded nicking of DNA, 5 to 10fold less frequently double-stranded breaks are produced |
| 3.1.21.2 | more |
Nfo-catalyzed nucleotide incision repair and exonuclease activities can generate a single-strand gap at the 5' side of 5,6-dihydrouracil residue |
| 3.1.21.2 | single-stranded DNA + H2O |
breakdown of host cell DNA occuring after T4 phage infection |
| 3.1.21.2 | single-stranded DNA + H2O |
the Ser176 of T4 endonuclease IV is crucial for the restricted and polarized dC-specific cleavage of single-stranded DNA implicated in restriction of dC-containing DNA in host Escherichia coli |
