EC Number   |
Natural Substrates |
|---|
   3.1.11.2 | double-stranded DNA + H2O |
exonuclease III and endonuclease IV remove 3'-blocks from DNA synthesis primers in H2O2-damaged E. coli |
| 3.1.11.2 | double-stranded DNA + H2O |
the principal biological role is the repair of DNA damage produced by free radicals |
| 3.1.11.2 | double-stranded DNA + H2O |
major apurinic/apyrimidinic DNA-repair endonuclease |
| 3.1.11.2 | double-stranded DNA + H2O |
the enzyme is essential for the repair of uracil-containg DNA and apyrimidine sites |
| 3.1.11.2 | double-stranded DNA + H2O |
the enzyme promotes in vitro binding of the replication initiator protein of plasmid pSC101 to the repeated sequences in the ori region |
| 3.1.11.2 | double-stranded DNA + H2O |
the enzyme is used to simultaneously quantify various types of DNA modifications, which are induced by agents that generate reactive oxygen species |
| 3.1.11.2 | double-stranded DNA + H2O |
the enzyme is required for stability of ColE1-related plasmids, pRSF2124 or pMB9, in E. coli. Any combination of exonuclease I, III and V deficiency results in dramatically decreased stability of the plasmids |
| 3.1.11.2 | double-stranded DNA + H2O |
one of two pathways of repair for hydrogen peroxide-induced DNA damage utilizes exonuclease III and DNA polymerase I |
| 3.1.11.2 | double-stranded DNA + H2O |
the enzyme is responsible for repair of many types of DNA damage that arise spontaneously under normal growth conditions |
| 3.1.11.2 | more |
the enzyme is a major AP endonuclease activity that is involved in efficient repair of oxidative lesions in bacterial DNA |
