EC Number   |
Natural Substrates |
|---|
   3.1.1.53 | 5-N-acetyl-9-O-acetylneuraminic acid + H2O |
- |
| 3.1.1.53 | CMP-O9-acetyl-N-acetylneuraminate + H2O |
SsNeuA is a bifunctional CMP-Neu5Ac synthetase/O-acetylesterase, which strictly de-O-acetylates CMP-O-acetyl-Neu5Ac |
| 3.1.1.53 | more |
O-acetyl esters |
| 3.1.1.53 | more |
specific for sialic acids and selectively cleaves acetyl groups at the 9-position. it deacetylates di-O-acetyl- and tri-O-acetyl-N-acetylneuraminic acids by first cleaving the O-acetyl ester at the 9-position. The 7- and 8-acetylesters then undergo spontaneous migration to the 9-position, where they can be cleaved |
| 3.1.1.53 | more |
O-acetylated sialic acids |
| 3.1.1.53 | more |
alpha-anomer specificity |
| 3.1.1.53 | more |
enhanced B-cell receptor signalling through hyper-9-O-acetylation of alpha2-6-linked sialic acid on N-glycans and defective CD22 inhibitory signalling in absence of the enzyme |
| 3.1.1.53 | more |
purified enzyme destroys BCoV receptors on rat erythrocytes and Madin-Darby bovine kidney (MDBK) cells |
| 3.1.1.53 | more |
Ser57 is essential for substrate binding and orientation and catalytic activity, NMR-analyses and molecular modelling |
| 3.1.1.53 | more |
MHV Sia receptor-binding specificity corresponds to the sialate-O-acetylesterase substrate preference of hemagglutinin-esterase , and hemagglutinin-esterase is sufficient to mediate virion binding to natural sialoglycoconjugates |
