EC Number   |
Natural Substrates |
|---|
    3.1.1.23 | 1-arachidonoylglycerol + H2O |
best substrate |
| 3.1.1.23 | 1-lauroyl-rac-glycerol + H2O |
more than 2fold higher activity compared to 1-oleoly-rac-glycerol |
| 3.1.1.23 | 2-arachidonoylglycerol + H2O |
- |
| 3.1.1.23 | 2-arachidonoylglycerol + H2O |
2-arachidonoylglycerol is an endocannabinoid which prevents the propagation of harmful neuroinflammation and may function as a gliotransmitter |
| 3.1.1.23 | 2-arachidonoylglycerol + H2O |
the enzyme is responsible for degradation of 2-arachidonoylglycerol in HeLa cells |
| 3.1.1.23 | 2-arachidonoylglycerol + H2O |
the enzyme is responsible for degradation of 2-arachidonoylglycerol in the brain |
| 3.1.1.23 | 2-arachidonoylglycerol + H2O |
MGL modulates endocannabinoid signaling in vivo by inactivating 2-arachidonoylglycerol (2-AG), the main endogenous agonist for central CB1 and peripheral CB2 cannabinoid receptors |
| 3.1.1.23 | 2-arachidonoylglycerol + H2O |
presynaptic MGL not only hydrolyzes 2-arachidonoylglycerol released from activated postsynaptic neurons but also contributes to degradation of constitutively produced 2-arachidonoylglycerol and prevention of its accumulation around presynaptic terminals. Thus, the MGL activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus |
| 3.1.1.23 | 2-oleoylglycerol + H2O |
- |
| 3.1.1.23 | arachidonoyl-7-hydroxy-6-methoxy-4-methylcoumarin ester + H2O |
- |
