EC Number   |
Natural Substrates |
|---|
   2.8.2.30 | 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine |
- |
| 2.8.2.30 | 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine |
isoform 3A modifies two novel tetrasaccharides of 3-O-sulfated heparan sulfate: deltaUA2S-GlcNS-IdoUA2S-S-GlcNH23S and deltaUA2S-GlcNS-IdoUA2S-3S-GlcNH23S6S |
| 2.8.2.30 | 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine |
3-O-sulfonation of heparan sulfate by isoenzyme 3A and 3B generates binding sites for the HSV-1 glycoprotein gD and initiation of virus entry |
| 2.8.2.30 | 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine |
isoforms 3A and 3B, isoform 3A transfers the sulfate group to IdoA2S-GlcNS, 3-O-sulfonation of glucosamine depends on the saccharide structure around the modified glucosamine residue |
| 2.8.2.30 | 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine |
3-O-sulfation of GlcNH2-containing heparan sulfate by 3-OST-3 provides binding sites for glycoprotein gD of Herpes simplex virus type I and is involved in involved in cyclosporine B, CyPB, binding and viral infection, analysis of heparin sulfate structures involve, overview |
| 2.8.2.30 | 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine |
3-OST-3 is involved in 3-OST-2-mediated HSV-1 entry into cells by catalyzing the preceeding step of 3-O-sulfated heparin sulfate modification of receptors |
| 2.8.2.30 | 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine |
modification of the heparan sulfate of glycoprotein D gD receptors required for entry of Herpes simplex virus simplex 1, 3-OST-3 and the herpesvirus entry mediator are involved, but not nectin-1 or nectin-2, in primary croneal fibroblasts, a natural target cell type, while HeLa cells use nectin-1 as the entry receptor, overview, 3-OS HS is required for HSV-1 glycoprotein-induced cell-to-cell fusion of cultured corneal fibroblasts |
| 2.8.2.30 | heparan sulfate + 3'-phosphoadenylyl sulfate |
i.e. PAPS |
| 2.8.2.30 | more |
heparan sulfate chains contain sulfated domains termed the HS fine structure, which gives HS specific binding affinities for extracellular ligands, heparan sulfate 3-O-sulfotransferases catalyze the transfer of sulfate groups to the 3-O position of glucosamine residues of heparan sulfate, a rare, but essential heparan sulfate chain modification required for HS fine structure |
| 2.8.2.30 | more |
HSV-1 glycoprotein-induced cell-to-cell fusion is inhibited by either prior treatment of cells with heparinases or by heparan sulfate preparations enriched in 3-OS HS, expression of HSV-1 gD in cultured corneal fibroblasts renders resistance to HSV-1 entry, overview |
