EC Number   |
Natural Substrates |
|---|
   2.7.8.17 | more |
the critical step in lysosomal targeting of soluble lysosomal enzymes is the recognition by an UDP-N-acetylglucosamine:lysosomal enzyme-N-acetylglucosamine-1-phosphotransferase |
| 2.7.8.17 | more |
the enzyme catalyzes the initial step in the synthesis of the mannose 6-phosphate determinant required for efficient intracellular targeting of newly synthesized lysosomal hydrolase to the lysosome |
| 2.7.8.17 | more |
phosphorylated recognition markers in lysosomal enzymes appear to be synthesized by transfer of alpha-N-acetylglucosamine 1-phosphate groups to C6 hydroxyl of mannose residues in glycosylated enzyme precursors and a subsequent hydrolysis from the diester groups of the N-acetylglucosamine residue |
| 2.7.8.17 | more |
enzyme catalyzes modification of lysosomal enzymes with mannose 6-phosphate. This modification is catalyzed by UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase. The modified lysosomal enzymes are then targeted to the lysosome |
| 2.7.8.17 | more |
the lysosomal integral membrane protein type 2 (LIMP-2/SCARB2) is a mannose 6-phosphate-independent trafficking receptor for beta-glucocerebrosidase and no substrate of the enzyme, M6P-independent lysosomal sorting of LIMP-2, overview. beta-Glucocerebrosidase is also no substrate for the enzyme |
| 2.7.8.17 | UDP-N-acetyl-D-glucosamine + lysosomal-cathepsin Z D-mannose |
- |
| 2.7.8.17 | UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose |
- |
| 2.7.8.17 | UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose |
initial enzyme in biosynthesis of mannose 6-phosphate |
| 2.7.8.17 | UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose |
substrates are lysosomal acid hydrolases |
