EC Number |
Natural Substrates |
---|
2.7.7.31 | a 2'-deoxyribonucleoside 5'-triphosphate + DNAn |
- |
2.7.7.31 | a 2'-deoxyribonucleoside 5'-triphosphate + single stranded DNAn |
- |
2.7.7.31 | a 2'-deoxyribonucleoside 5'-triphosphate + single stranded DNAn |
the enzyme catalyzes the elongation of a DNA with the length of three or more nucleotides by the isothermal and repetitive addition of deoxyribonucleotides to the 3'-OH terminus of DNA molecules |
2.7.7.31 | deoxynucleoside triphosphate + DNA |
involved in creating somatic diversity of immunoglobulin and T-cell receptor genes |
2.7.7.31 | deoxynucleoside triphosphate + DNA |
roles in DNA replication and repair processes |
2.7.7.31 | deoxynucleoside triphosphate + DNA |
hypothesis: terminal transferase acts as a somatic mutator, diversifying the amino acid sequence in the variable region of immunoglobulin molecules by changing one of the nucleotides |
2.7.7.31 | deoxynucleoside triphosphate + DNA |
enzyme may act as a random-sequence generator in highly localized regions of the DNA, enzyme may be an intracellular marker for a subpopulation of cells |
2.7.7.31 | deoxynucleoside triphosphate + DNA |
the enzyme has a key role in V(D)J recombination during lymphocyte and repertoire development |
2.7.7.31 | deoxynucleoside triphosphate + DNAn |
the long murine terminal deoxynucleotidyltransferase isoform does not play a role in the control of V(D)J junctional diversity |
2.7.7.31 | more |
alternative splicing seems to regulate TdT isoform expression. Both long isoforms, hTdTL1 and hTdTL2 have 3'-5' exonuclease activity. Overexpression of the short isoform hTdTS or the long isoform hTdTL2 greatly reduces the efficiency of recombinantion, which is reverted to normal levels by simultaneous expression of both enzymes |