EC Number   |
Natural Substrates |
|---|
   2.7.11.23 | ATP + HIV Tat |
- |
| 2.7.11.23 | ATP + RNA polymerase II C-terminal domain |
the SRI domain of Set2 interacts with the phosphorylated CTD of elongating RNAPII leading to methylation of the chromatin during transcription |
| 2.7.11.23 | ATP + RNA polymerase II C-terminal domain |
Ctk1 kinase activity regulates H3K4 methylation, the Ctk2 and Ctk3 components of CTDK-1 are necessary for Ctk1 kinase activity, overview |
| 2.7.11.23 | ATP + RNA polymerase II C-terminal domain |
TFIIH, a 10-subunit complex with many resident enzymatic activities, is essential for transcription by RNA polymerase II involving the TFIIH-associated kinase, Cdk7, which phosphorylates the C-terminal domain, CTD, of Rpb1, the largest subunit of Pol II |
| 2.7.11.23 | ATP + RNA polymerase II C-terminal repeat domain |
hyperphosphorylation, the Mediator complex associates with RNA polymerase II, RNAPII, at least partly via the RNAPII C-terminal repeat domain, CTD, whose phosphorylation is involved in triggering promoter clearance |
| 2.7.11.23 | ATP + RNA polymerase II C-terminal subunit |
i.e. RNAP II CTD, hypophosphorylated form of RNAP IIa is recruited to the preinitiation complex at the gene promoter by the general transcription factors. Initiation proceeds when the cdk7 complex phosphorylates the CTD at the serine 5 residues, resulting in a hyperphosphorylated RNAP II that recruits the RNA-capping enzymes, overview |
| 2.7.11.23 | ATP + RNA polymerase II C-terminal subunit |
Positive transcription elongation factor b is the major metazoan RNA polymerase II carboxyl-terminal domain Ser2 kinase, P-TEFb is critical for the maturation of RNA PolII into productive elongation in vivo, overview |
| 2.7.11.23 | ATP + RNA polymerase II C-terminal subunit |
the enzyme regulates transcription elongation at many genes and integrates mRNA synthesis with histone modification, pre-mRNA processing, and mRNA export. Recruitment of P-TEFb to target genes requires deubiquitination of H2Bub, phosphorylation of H3S10, and the bromodomain protein, Brd4, overview. P-TEFb accompanies the mature mRNA to the cytoplasm to promote translation elongation. Enzyme regulation system, detailed overview |
| 2.7.11.23 | ATP + RNA polymerase II C-terminal subunit |
the TFIIH mediator complex plays essential roles in transcription initiation and during the transition from initiation to elongation by transmitting signals from transcriptional activators to RNA polymerase II, phosphorylation of the C-terminal domain of RNA polymerase II plays central roles in the integrated events of eucaryotic gene expression, it is not only essential for transcription, but also as a platform for RNA processing and chromatin regulation, detailed overview |
| 2.7.11.23 | ATP + RNA polymerase II carboxy terminal domain |
the phosphorylated RNAPII CTD, interacts with BRCA1 for induction of DEF1-dependent cleavage and accumulation of a RNAPII fragment containing the P-CTD, overview |
