EC Number |
Natural Substrates |
---|
2.7.11.21 | ATP + 20S proteasome |
phosphorylation by Plk1 enhances the proteolytic activity |
2.7.11.21 | ATP + 3F3/2 kinase |
the enzyme creates the 3F3/2 kinase phosphoepitope on mitotic kinetichores, depletion of enzyme in M phase cell extract leads to loss of 3F3/2 kinase activity |
2.7.11.21 | ATP + 53BP1 |
53BP1 is phosphorylated by Plk1 in mitosis |
2.7.11.21 | ATP + 85kDa microtubule-associated protein |
protein is released from microtubules after phosphorylation |
2.7.11.21 | ATP + a protein |
- |
2.7.11.21 | ATP + abnormal spindle pole protein |
i.e. abnormal spindle pole protein, activation of abnormal spindle pole protein by phosphorylation |
2.7.11.21 | ATP + BubR1 |
- |
2.7.11.21 | ATP + BubR1 |
S676 is an in vivo Plk1 phosphorylation site in BubR1 |
2.7.11.21 | ATP + casein |
kinase assay |
2.7.11.21 | ATP + Cdc25C |
phosphorylation by Plk1 on Ser198 in a nuclear export signal sequence promoting its nuclear translocation, inhibition of Cdc25 activation resulting in a delay in Cdc2 activation |