EC Number   |
Natural Substrates |
|---|
   2.7.11.2 | ATP + Pda1p subunit |
the enzyme is the kinase of the Saccharomyces cerevisiae pyruvate dehydrogenase complex, which negatively regulates the complex by reversible phosphorylation of its Pda1p subunit, overview |
| 2.7.11.2 | ATP + pyruvate dehydrogenase |
- |
| 2.7.11.2 | ATP + pyruvate dehydrogenase |
a small pocket in the N-terminal region of PDHK2 is involved in enzyme regulation, the pocket is formed by residues L53, Y157, Y80, S83, I111, R112, H115, S153, R154, I157, R158, I161 |
| 2.7.11.2 | ATP + pyruvate dehydrogenase |
enzyme has an important role in control of glucose homeostasis |
| 2.7.11.2 | ATP + pyruvate dehydrogenase |
PDHK plays a key role in controlling the balance between glucose and lipid oxidation according to substrate supply, PDHK inhibition leads to increased PDH activity increasing glucose oxidation |
| 2.7.11.2 | ATP + pyruvate dehydrogenase |
PDK is involved in fatty acid metabolism |
| 2.7.11.2 | ATP + pyruvate dehydrogenase |
phosphorylation by PDK inhibits the pyruvate dehydrogenase complex, PDK plays a regulatory role in glucose metabolism, PDK4 expression is regulated by hepatic nuclear factor 4 and peroxisome proliferator-activated receptor gamma coactivator, PGC-1alpha |
| 2.7.11.2 | ATP + pyruvate dehydrogenase |
phosphorylation of E2-bound E1 |
| 2.7.11.2 | ATP + pyruvate dehydrogenase |
pyruvate dehydrogenase kinase is a negative regulator in the mitochondrial pyruvate dehydrogenase complex and plays a pivotal role in controlling TCA cycle and cell respiration |
| 2.7.11.2 | ATP + pyruvate dehydrogenase complex |
- |
